| Date | Home | Away | Result |
|---|---|---|---|
| 21/01/25 17:45 | AS Monaco | Aston Villa | 1-0 |
| 21/01/25 17:45 | Atalanta Bergamo | SK Sturm Graz | 5-0 |
| 21/01/25 20:00 | Liverpool FC | OSC Lille | 2-1 |
| 21/01/25 20:00 | Atletico Madrid | Bayer 04 Leverkusen | 2-1 |
| 21/01/25 20:00 | Club Brugge | Juventus Turin | 0-0 |
| 21/01/25 20:00 | Red Star Belgrad | PSV Eindhoven | 2-3 |
| 21/01/25 20:00 | SK Slovan Bratislava | VfB Stuttgart | 1-3 |
| 21/01/25 20:00 | FC Bologna | Borussia Dortmund | 2-1 |
| 21/01/25 20:00 | Benfica Lisbon | FC Barcelona | 4-5 |
| 22/01/25 17:45 | Schachtjor Donezk | Stade Brest 29 | --- |
| 22/01/25 17:45 | RB Leipzig | Sporting Lisbon | --- |
| 22/01/25 20:00 | Arsenal FC | Dinamo Zagreb | --- |
| 22/01/25 20:00 | AC Milan | FC Girona | --- |
| 22/01/25 20:00 | Real Madrid | FC Red Bull Salzburg | --- |
| 22/01/25 20:00 | Paris St. Germain | Manchester City | --- |
| 22/01/25 20:00 | Celtic Glasgow | Young Boys Bern | --- |
| 22/01/25 20:00 | Feyenoord Rotterdam | FC Bayern Munich | --- |
| 22/01/25 20:00 | Sparta Prag | Inter Milan | --- |